The 3C-like serine protease activity of porcine astrovirus nsP1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response

Author summary Porcine astrovirus (PAstV) is widespread in pigs, posing a threat to the pig industry’s sustainability, with no effective drugs or vaccines available. This study explored the mechanisms by which PAstV modulates apoptosis and innate immunity. Ou…