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The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts

The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts

Published: April 6, 2026 · Plos.org

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Emerging research has highlighted the regulatory roles of m6A RNA modifications on bone homeostasis, but the function of m6Am modifications are not as well understood. This study shows that the PCIF1 m6Am methyltransferase supports bone mass maintenance by st…