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Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging

Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging

Published: April 5, 2026 · Nature.com

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How hematopoietic stem cells resist stress yet lose function with age remains unclear. This study identifies a non-canonical role for MLKL that impairs mitochondria without killing cells and contributes to age-related decline in hematopoietic stem cell functi…