Development of a monoclonal antibody-based competitive ELISA as a surrogate assay for detecting neutralizing anti-interferon gamma autoantibodies in adult-onset immunodeficiency

Neutralizing anti-interferon gamma autoantibodies (nAIGAs) play a pivotal role in the pathogenesis of adult-onset immunodeficiency (AOID), predisposing affected individuals to severe opportunistic infections. Current detection of nAIGAs relies on cell-based a…