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Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies

Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies

Published: February 27, 2026 · Plos.org

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Author summary Diversity Outbred (DO) mice are a powerful system for studying the genetics of complex traits, but many of the techniques that are useful for human genetic studies have not been adapted for use with them. Here, we implement a method for DO’s – …