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Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms

Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms

Published: June 5, 2026 · Plos.org

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Biofilm matrices containing filamentous phages enable Pseudomonas aeruginosa to tolerate antibiotics. This study shows that nanobody disruption of phage Pf4 liquid crystalline droplets restores antibiotic susceptibility, highlighting a biophysical alternative…