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Mannose-binding lectin 2 secreted by hepatocellular carcinoma cells recruits and activates natural killer cells to reshape an immune-activated microenvironment

Mannose-binding lectin 2 secreted by hepatocellular carcinoma cells recruits and activates natural killer cells to reshape an immune-activated microenvironment

Published: May 20, 2026 · Plos.org

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Natural killer (NK) cells have a main role in the tumor microenvironment, but the mechanisms underlying their activity in hepatocellular carcinoma remain unclear. This study shows that mannose-binding lectin 2 (MBL2) secreted by hepatocellular carcinoma cells…