Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation

The authors identified a series of covalent, monovalent glue degraders that can co-opt two E3 ligases, DCAF16 and FBXO22, in a parallel fashion to degrade SMARCA2/4 and demonstrated that ligase preference can be chemically and genetically tuned.