Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum: Implications for antiparasitic development

Author summary Schistosomiasis, a devastating neglected tropical disease (NTD), affects approximately 240 million individuals and puts over 700 million at risk. While praziquantel (PZQ) is the only available therapeutic, it faces significant limitations, high…