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Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation

Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation

Published: February 19, 2026 · Plos.org

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Author summary Toxoplasma gondii is a common parasite that can infect nearly all warm-blooded animals, including humans. While healthy individuals usually do not develop symptoms, those with weakened immune systems may suffer from severe disease. The host def…